| abstract |
The invention provides a surface denatured protein biofunctional modification material, a preparation method and application thereof. First, the conformation of protein molecules such as fibrinogen is regulated by using an organic solvent, and then a certain post-treatment is performed to obtain a surface biomaterial. Functionalized Modified Materials. Controlling the proportion of organic solvent added can make protein molecules produce different conformational changes, and the self-assembled structures exposed on the surface of the material have different recognizable sites, which can induce different cellular response behaviors. The method of the invention is simple and controllable, green and environmentally friendly, and has relatively low cost, which can not only effectively improve the biological activity of the material surface, but also induce different cell response behaviors. |