http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113117140-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2021-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113117140-B |
| titleOfInvention | Preparation method of double-stimulus synergistic response porous hydrogel modified acrylic acid bone cement |
| abstract | The invention discloses a preparation method of porous hydrogel modified acrylic acid bone cement with double stimulus synergistic response, which comprises the following steps: the method comprises the steps of preparing pH-temperature sensitive hydrogel microspheres by using acrylic acid, alpha-methacrylic acid and N-isopropylacrylamide as raw materials, preparing a porous hydrogel drug-loaded scaffold by an etching silica gel crystal template method, and compounding the porous hydrogel drug-loaded scaffold and the porous hydrogel drug-loaded scaffold to form a three-dimensional porous high drug-loaded scaffold in acrylic acid bone cement by using the double-stimulus response porous hydrogel microspheres. After the acrylic acid bone cement is injected into a human body, the double-stimulation cooperative response porous hydrogel drug-loaded swelling acrylic acid bone cement can release drugs according to the abnormal changes of pH and temperature in a local microenvironment, when the microenvironment returns to normal drug release and stops, the long-acting controllable release can be kept on the basis of the release as required, and meanwhile, the porous structure provides conditions for promoting bone ingrowth. The bone cement prepared by the method improves the problem of volume shrinkage of acrylic bone cement, and meets the clinical medical requirement of high drug loading, long-acting and controllable release. |
| priorityDate | 2021-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.