| abstract |
The invention discloses a heat-stable ACWY135 group meningitis-JE combined vaccine soluble micro-needle patch, comprising a needle body and a backing, wherein the needle body is composed of the ACWY135 group meningitis-JE combined vaccine, a stabilizer and a Matrix material composition, wherein, the stabilizer is a mixture of sodium glutamate and raffinose. The ACWY135 group meningitis-JE combined vaccine soluble microneedle prepared by the invention has good immune effect and high mechanical strength of the needle body, and is expected to replace the existing combined injection of meningitis vaccine and JE vaccine, and realize painless and minimally invasive administration. medicine. |