| abstract |
The invention discloses an anti-recombinant human basic fibroblast growth factor nano antibody and application thereof. The anti-recombinant human basic fibroblast growth factor nano antibody has the characteristics of small molecular weight, strong specificity, high affinity, high stability, easy expression, strong cell/blood vessel penetrability, strong antigen binding capacity, capability of being expressed in a prokaryotic expression system and the like, overcomes the defects of long development period, low stability, harsh storage conditions and the like of the traditional antibody, can effectively neutralize the over-expressed bFGF in the body of a patient with tumor and fibrosis, can effectively inhibit the generation of blood vessels and the growth and transfer of the tumor, and can also be used for inhibiting the formation of fibrosis of the liver, the lung or the kidney and the like. Meanwhile, the nano antibody can realize high-efficiency expression in escherichia coli, and has good application prospect in tumor antibody treatment medicines or cancer diagnosis kits or reagents. |