http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113101369-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113101369-B |
| titleOfInvention | Application of circular RNA circ-RNF13 as target site inhibitor |
| abstract | The invention discloses application of a circular RNA circ-RNF13 as an inhibitor of a target site in preparation of a paclitaxel sensitizing drug for treating nasopharyngeal carcinoma. The research of the invention shows that the cyclic RNA circ-RNF13 in the nasopharyngeal darcinoma taxol-resistant cell strain is highly expressed, and the circ-RNF13 is knocked out to increase the taxol medicine sensitivity of nasopharyngeal darcinoma cells. Therefore, the circ-RNF13 can be used as a target site in the preparation of a nasopharyngeal carcinoma paclitaxel sensitization medicine and is also a molecular marker for clinically predicting the paclitaxel drug sensitivity of a nasopharyngeal carcinoma patient. Mechanism research shows that the circ-RNF13 with high expression can promote ubiquitination degradation of p53 protein by ubiquitination ligase TRIM41 protein to cause the drug resistance of nasopharyngeal carcinoma cells to paclitaxel. |
| priorityDate | 2021-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.