http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113101264-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2305-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-722 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 |
| filingDate | 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113101264-B |
| titleOfInvention | Hydrogel with ROS response and preparation method and application thereof |
| abstract | The invention provides a hydrogel with ROS response and a preparation method and application thereof. And then, taking cystamine as a cross-linking agent, and enabling amino groups of the cystamine and benzoquinone formed after catechol groups are oxidized to generate Michael addition reaction to form a cross-linked network, thereby forming the hydrogel. The invention also comprises the hydrogel with ROS response prepared by the method and application thereof. The disulfide bond contained in cystamine can be broken under the action of active oxygen and converted into sulfinic acid, so that the structure of hydrogel is damaged, the function of intelligently releasing the medicine can be exerted in the atherosclerosis part which generates more active oxygen substances, the sudden release of the medicine in the pathological change part is avoided, and the risks of intravascular restenosis, delayed endothelial healing, late thrombus and the like are hopefully reduced. |
| priorityDate | 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.