| abstract |
The invention belongs to the technical field of antitumor drugs, and in particular relates to a drug carrier, a drug-carrying system and a preparation method and application thereof. The present invention provides a drug carrier comprising mesoporous silica, a polydopamine layer wrapped on the surface of the mesoporous silica, and ferric ions chelated on the surface of the polydopamine. In the present invention, the ferric ions chelated on the surface of the drug carrier can decompose a large amount of hydrogen peroxide accumulated in the tumor tissue to generate oxygen, thereby alleviating the problem of hypoxia in photodynamic therapy; Reduced to divalent iron ions, the reduced divalent iron ions and hydrogen peroxide can generate hydroxyl radicals through the Fenton effect, thereby improving the effect of chemodynamic therapy. |