| abstract |
The invention belongs to the technical field of medicine, and in particular relates to a penehyclidine hydrochloride nanomedicine and a preparation method thereof. The penehyclidine hydrochloride nanomedicine provided by the invention comprises penehyclidine hydrochloride, natural polyphenol, sodium alginate, liposome, cross-linking agent and water for injection. The penehyclidine hydrochloride nano-medicine provided by the invention prolongs the action time of penehyclidine hydrochloride and improves the drug effect; firstly, it is wrapped once by using natural polyphenol, sodium alginate and cross-linking agent, and then using lipid The body is wrapped twice, which effectively avoids the phenomenon of pH value change and drug efficacy reduction of penehyclidine hydrochloride in long-term storage. In addition, the preparation method of the penehyclidine hydrochloride nanomedicine provided by the present invention is simple and the conditions are controllable, which is favorable for realizing industrialized production. |