| abstract |
The invention relates to the field of pharmacy, in particular to Hypericum perforatum extract and its components for inhibiting novel coronavirus 3CLpro or SARS coronavirus 3CLpro in the preparation of medicines or daily external disinfectant lotion products for inhibiting novel coronavirus 3CL protease or SARS coronavirus 3CL protease The Hypericum perforatum extract contains 0.3% hypericin and can be prepared by the following method: after drying Hypericum perforatum, use a pulverizing machine to powder, and pass through a 40-mesh sieve to obtain Hypericum perforatum fine powder; Forsythia frondosa fine powder was placed in 500 mL of distilled water, sonicated at 50 °C for 30 minutes, filtered to obtain a crude extract of Hypericum perforatum, repeated extraction three times, and the extracts were combined, and then centrifuged at a high speed of 12,000 r/min for 20 minutes to obtain the supernatant; The supernatant was concentrated to 50 mL under reduced pressure and dried. The components of the Hypericum perforatum for inhibiting novel coronavirus 3CLpro or SARS coronavirus 3CLpro are selected from hypericin, pseudohypericin or pro-hypericin. |