| abstract |
The invention discloses a class of amide compounds and derivatives thereof, preparation methods, pharmaceutical compositions and applications. The structure of this type of amide compound is shown in formula (I), and this type of amide compound derivative is related to the stereoisomer, tautomer, metabolite, metabolic precursor, prodrug, solvate and solvate of the amide compound. Salts, crystalline, pharmaceutically acceptable salts or mixtures thereof. The amide compounds and their derivatives have high inhibitory effect on indoleamine 2,3-dioxygenase 1, and can be used to prepare and treat indoleamine 2,3-dioxygenase 1-mediated immunosuppression-related diseases The prepared medicine can exert the medicinal effect at the molecular level, and is widely used, and the synthesis method of the compound is simple and easy to operate. |