| abstract |
The invention discloses a PARP-1/PI3K dual-target inhibitor or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. The single active ingredient of the present invention can exert the dual inhibitory effect on PARP-1 and PI3K, reduce the dosage, improve the therapeutic effect, and reduce the toxic and side effects; the dual inhibitory effect on PARP-1 and PI3K is remarkable, and the IC 50 value of each target No more than 1.0 μM, and its drug as an active ingredient can be used to treat various cancers or tumors related to PARP-1 and/or PI3K. |