http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113045485-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-4283 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-1625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 |
| filingDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113045485-B |
| titleOfInvention | A kind of continuous production method of amiloride |
| abstract | The invention discloses a continuous production method of amiloride. Using tetraclopyralid as a raw material, the product amiloride is obtained through salt formation, ammoniation and acidification, wherein the ammoniation reaction of the present invention is carried out in a tower reactor In the continuous process, the tower reactor is provided with a reaction zone and a stripping deamination zone, the catalyst layer is arranged in the reaction zone, tetraclopyridinate and ammonia are continuously fed into the tower reactor, and in the reaction zone carry out the ammoniation reaction. The invention avoids the large-capacity kettle-type process in the traditional process route, reduces the safety risk of the reaction; at the same time, due to the catalysis of the catalyst, the reaction time is shortened, the occurrence of side reactions is reduced, and it is more green, efficient, safe and reliable. The overall process of the invention is simple and convenient, and the reaction conditions are mild. By adjusting the reaction conditions, the yield of the obtained product is high, which is beneficial to industrial production. |
| priorityDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.