http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113045469-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65bc1009ea022b298a8ce68d1e9c3834 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-267 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-267 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-76 |
| filingDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7cd0461a80de1561ce8af9d23c9ebe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cba62f2a27fbbf85ad243cab5bf8e95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_745714ded21f02ea6cc48bf3be1279ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02ace4bc264193ca5f97149013998b54 |
| publicationDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113045469-A |
| titleOfInvention | A kind of synthetic method of lactam compound |
| abstract | The invention discloses a method for synthesizing a lactam compound. (1) Under gas protection, N-F benzenesulfonamide and acid chloride are dissolved in an organic solvent and stirred evenly, and the reaction is performed to obtain a crude product; (2) the crude product is obtained by the reaction. Recrystallization to obtain product A; (3) product A, cuprous iodide and o-phenanthroline obtained in step (2) are dissolved in a mixed organic solvent and heated to react to obtain an intermediate; (4) the intermediate is dissolved and added Tetrabutylammonium fluoride was stirred to obtain the target product. The invention selects commercially available N-F benzenesulfonamide and acid chloride as starting materials, and the materials are easy to obtain; the synthesis method of the invention selects commercially cheap and easily available cuprous iodide as the catalyst, avoiding the use of expensive precious metals The whole synthesis method of the present invention has mild reaction conditions; the present invention obtains the target compound through free radical cyclization, avoids the use of other oxidants or precious metal catalysts, and has low synthesis cost. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022199124-A1 |
| priorityDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.