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publicationDate 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113042118-A
titleOfInvention Surface modification PMMA microfluidic chip, modification method and application
abstract A surface-modified PMMA microfluidic chip, modification method and application, characterized in that: the chip is esterified by sodium hydroxide, then carboxylated with hydrochloric acid, and then 1-(3-dimethylaminopropyl)-3 It is obtained by further activating the chip by the mixed solution of ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. In this application, the surface modification of PMMA chip with a specific structure and composition is specifically designed to hydrolyze under alkaline conditions, introduce hydrophilic groups under acidic conditions, and then activate them. Such specific steps and The solution enables the PMMA chip finally obtained in the present application to reflect ultra-high detection sensitivity, wide detection range and high absolute sample signal intensity after use.
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