http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113016719-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113016719-B |
| titleOfInvention | Preparation method of a model of synuclein pathological REM sleep behavior disorder |
| abstract | The present invention relates to a method for inducing a rapid eye movement sleep behavior disorder (RBD) phenotype that can be converted to a Parkinson's phenotype in a non-human test animal, the method comprising 1) unilateral treatment of the non-human test animal Or bilateral pontine tegmental dorsolateral inferior nucleus (SLD) stereotaxic injection of substances capable of inducing pathological changes in synuclein; 2) Assess the induction of RBD phenotype in the non-human test animals; 3) In the described Induction of Parkinsonian phenotypes was assessed in RBD animals. The invention also relates to a preparation method of a synuclein pathological RBD model. The present invention proposes to inject prefabricated fibrils (PFFs) that can induce synuclein pathology into SLD nuclei in a stereotaxic manner. It is expected that this model can provide an important animal model basis for elucidating the etiology, pathogenesis, and Parkinson's outcome of RBD in future research and developing effective blocking drugs. |
| priorityDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.