| abstract |
The invention discloses a method for determining the content of oxycodone hydrochloride by high performance liquid chromatography. The method uses a mixed solution of acetic acid aqueous solution and methanol as an extracting solution, and the extracting solution has good solubility for oxycodone hydrochloride, and can limit the concentration of oxycodone hydrochloride to the greatest extent. Codone was extracted, and then used C18 chromatographic column, sodium heptane sulfonate buffer as aqueous phase and methanol and acetonitrile mixture as organic phase as mobile phase for chromatographic analysis; the method is simple in operation, accurate in measurement and good in repeatability. |