http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113004352-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113004352-B |
| titleOfInvention | Preparation method of fondaparinux sodium and fondaparinux sodium monosaccharide intermediate |
| abstract | The invention discloses a fondaparinux sodium and a preparation method of a fondaparinux sodium monosaccharide intermediate, which takes glucosamine protected at C4 and C6 as raw materials, obtaining methyl 3-O-benzyl-4, 6-O-benzylidene-2- (benzyloxycarbonyl) amino-2-deoxy-alpha-D-glucopyranoside through methylation, amidation and benzylation, then, a dehydroxylation protecting group protection reaction is carried out to obtain a fondaparinux sodium monosaccharide fragment intermediate methyl3-O-benzyl-2- (benzyloxycarbonyl) amino-2-deoxy-alpha-D-glucopyranoside, and the fondaparinux sodium is prepared from the intermediate methyl3-O-benzyl-2- (benzyloxycarbonyl) amino-2-deoxy-alpha-D-glucopyranoside. The preparation method has the advantages of simple process, less side reaction impurities and high yield, and is suitable for large-scale preparation of fondaparinux sodium in order to meet the requirement of industrial production of fondaparinux sodium. |
| priorityDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.