http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113004241-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113004241-B |
| titleOfInvention | 11,20-Dicarbonyl Jiyuan Rubescensine A 14-O-benzoate derivative and its preparation method and use |
| abstract | The invention relates to the field of natural products and medicinal chemistry, and discloses 11,20-dicarbonyl Jiyuan oridonin A 14-O-benzoate derivative and a preparation method and application thereof. Its preparation method: taking Jiyuan Rubescensine A (JOA) as a starting material, oxidizing it to obtain 11,20-dicarbonyl Jiyuan Rubescensine A, and then without destroying its active center α-methylene group. Under the premise of cyclopentanone, benzoic acid or substituted benzoic acid and its 14-OH undergo esterification to obtain a series of 11,20-dicarbonyl Jiyuan Rubescensine A 14-O-benzoate derivatives. The compounds have good anti-tumor activity and can be used for preparing anti-cancer drugs and treating diseases such as esophageal cancer, gastric cancer, liver cancer, breast cancer, pancreatic cancer and the like. Its general structural formula is as follows: |
| priorityDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.