| abstract |
The present disclosure is based, at least in part, on the following findings: high purity PEG lipids exhibit excellent physical and biological properties, particularly when used in Lipid Nanoparticle (LNP) formulations. Thus, the present disclosure provides PEG lipids of recommended purity, e.g., for use in formulations such as LNP formulations. The present disclosure also provides LNPs comprising the high purity PEG lipids and methods of using the LNPs to deliver therapeutic agents to a subject. |