http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112980834-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-686 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-686 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2021-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112980834-B |
| titleOfInvention | A homologous recombination repair defective reference product and its preparation method and kit |
| abstract | The invention discloses a homologous recombination repair defect reference product, a preparation method and a kit thereof. The reference product is obtained by mixing genomic DNAs extracted from 10 pairs of paired cell lines according to a certain ratio, and the gradient reference is determined by whole genome sequencing. The homologous recombination repair defect value of the corresponding gradient reference product is calculated by a specific bioinformatics algorithm; while the detection limit reference product is obtained by diluting the tumor cell sample with the normal cell sample in the paired sample, and using the droplet digital The PCR method verifies the dilution ratio to ensure that the mixing meets expectations, so as to simulate the complexity of clinical samples and the specificity and sensitivity of the detection system to the greatest extent; this reference product can be used for the performance evaluation of homologous recombination repair defect detection products, and also It can be used for algorithm optimization or detection process optimization of homologous recombination repair defects, and is suitable for high-throughput nucleotide polymorphism gene chips, targeted genome or whole genome sequencing strategies. |
| priorityDate | 2021-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.