http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112980799-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8775 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-877 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112980799-B |
| titleOfInvention | A method for constructing KLF12 high-expression mice and its application in the construction of non-folate-dependent neural tube defect mouse models |
| abstract | The invention discloses a method for constructing KLF12 high-expressing mice and its application in constructing a non-folate-dependent neural tube defect (neural tube defects, NTDs) mouse model, which includes using Cre-loxP gene recombination according to the Klf12 gene sequence technology to construct Rosa26 Klf12/Klf12 mice; the Rosa26 Klf12/Klf12 mice were mated with Sox Cre female mice, and the KLF12 high-expression embryos obtained were non-folate-dependent neural tube defect mouse models, which could It is used in the preparation or development of screening therapeutic candidate drugs and health care products. The present invention is the first to construct an animal model of non-folate-dependent NTDs caused by high-level KLF12. This model is similar to human patients with non-folate-dependent NTDs. It has good clinical symptom simulation and high stability, and is very beneficial for mechanism research and drug screening. . |
| priorityDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.