| abstract |
Purification of target biomolecules such as nucleic acids or proteins from biological sources is a time-consuming process, usually performed by skilled technicians or scientists due to the highly technical nature of the work. The systems, devices and methods disclosed herein enable automated biological processing and purification of target biomolecules in biological sources. For example, the present invention provides an instrument and disposable purification column for the automated isolation and purification of nucleic acids (eg, plasmid DNA from bacterial cultures) or protein isolation from any biological sample. Such exemplary instruments and purification columns work together to release, mix and move target biomolecules and various reagents and buffers in time during target biomolecule purification, resulting in purified targets that require less human oversight than traditional methods Biomolecules. |