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filingDate 2021-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ed061fd686b962f2d0e62c3cc363e00
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publicationDate 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112979939-A
titleOfInvention A kind of multi-arm polyethylene glycol-based polyphenol compound and coating preparation and application method thereof
abstract The invention discloses a multi-arm polyethylene glycol-based polyphenol compound and a method for preparing and applying the coating thereof. The provided multi-arm polyethylene glycol-based polyphenol compound is synthesized by a solution one-pot method, and can be obtained by simple separation The product has simple preparation process, easy operation and high yield. The multi-arm polyethylene glycol amine and phenolic form a Schiff base reaction, and a polyphenol structure is introduced at the end of the multi-arm polyethylene glycol, which can chelate metal ions to form a cyclic chelate. The invention also provides a preparation method of a multi-arm polyethylene glycol-based polyphenol compound and a coating thereof. The target modified material is soaked in a mixed solution composed of the multi-arm polyethylene glycol-based polyphenol compound and a soluble metal salt. A metal network framework coating is constructed on its surface, which cooperates with polyethylene glycol (PEG) to improve the biocompatibility of the material, and has potential application prospects in the surface modification of cardiovascular and other implant materials.
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