http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112979643-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-716 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-716 |
| filingDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112979643-B |
| titleOfInvention | 3- (2-chloroethyl) -9-hydroxy-2-methyl-4H-pyrido [1,2-a ] pyrimidin-4-one |
| abstract | The invention provides 3- (2-chloroethyl) -9-hydroxy-2-methyl-4H-pyrido [1,2-a ] pyrimidine-4-ketone, which is prepared by performing substitution reaction on ethyl acetoacetate and 1-bromo-2-chloroethane under an alkaline condition to obtain 2-acetyl-4-chlorobutyric acid ethyl ester, and then reacting the 2-acetyl-4-chlorobutyric acid ethyl ester with 3-hydroxy-2-aminopyridine. Compared with the existing preparation method of paliperidone, the preparation method of the intermediate 3- (2-chloroethyl) -9-hydroxy-2-methyl-4H-pyrido [1,2-a ] pyrimidine-4-ketone can avoid the use of highly polluting chlorinating agents, such as: thionyl chloride, phosphorus oxychloride and the like, does not generate waste gas and waste liquid, has cheap and easily obtained raw materials, does not need harsh reaction conditions, has excellent yield and purity, high safety, simple and convenient operation and high process economy, and is suitable for industrial production. |
| priorityDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.