http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112961337-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G2650-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G2650-38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33396 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 |
| filingDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112961337-B |
| titleOfInvention | Glycindiazole sodium polyethylene glycol polyaspartic acid polymer and preparation method thereof |
| abstract | The invention discloses a glycididazole sodium polyethylene glycol polyaspartic acid polymer. The glycidiazole sodium polyethylene glycol polyaspartic acid polymer of the present invention is a new polymer synthesized for the first time. Glycine bisazole sodium undergoes esterification reaction with R-diol under the action of DMAP and EDCI to obtain intermediate (I), and then (I) and (II) undergo esterification reaction again under the action of DMAP and BOP-Cl to obtain the Copolymer is required. Moreover, pharmacological tests have shown that the glycididazole sodium polyethylene glycol polyaspartic acid polymer of the present invention can increase the targeting of adriamycin drugs, gather adriamycin drugs in tumor cells through the EPR effect, and can be used as The drug carrier of doxorubicin targets tumor cells, therefore, the sodium glycidiazole polyethylene glycol polyaspartic acid polymer of the present invention can be used in combination with doxorubicin to prepare the antitumor drug doxorubicin (DOX) Targeted micellar formulations of drugs. |
| priorityDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.