http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112961182-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87b3f9f9968c1dfd87f754a4e66a357f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 |
| filingDate | 2021-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b08803d53d4aa472dfe98fcc2813c41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_782f2f527d4264bf3940d971b59569c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44c1069fa2a863be555ea2fab9cb48ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ff6c3152b9c5e603a139f7a2712051a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a890c61a43a5fd57f0a067416e84bed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7073b1f00a7423ad03f2971b8ad9aa50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eae20cdcc18ac57350651fee571ea43 |
| publicationDate | 2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112961182-A |
| titleOfInvention | A kind of method for preparing tetraethyl methylene diphosphonate |
| abstract | The invention relates to the field of pharmaceutical synthesis, and discloses a method for preparing tetraethyl methylene diphosphonate. The method comprises: (1) firstly mixing sodium methoxide and an organic solvent to obtain a first mixed solution; (2) ) carrying out the second mixing of the first mixed solution and diethyl phosphite to obtain the second mixed solution containing sodium diethyl phosphite; (3) carrying out the distillation treatment of the second mixed solution to obtain phosphorous acid Sodium diethyl ester; (4) thirdly mixing the sodium diethyl phosphite and dihalomethane to obtain tetraethyl methylene diphosphonate. In the method provided by the invention, tetraethyl methylene diphosphate can be prepared by using sodium methoxide, avoiding the use of highly dangerous metal sodium and sodium hydride, and the yield is equivalent to the existing metal sodium or sodium ethoxide. The invention provides an economical and safe process method for the preparation of tetraethyl methylene diphosphate. |
| priorityDate | 2021-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.