| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c27f4a786895417d03d0b1045587100 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 |
| filingDate |
2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464f4e31e1893c7202d5c7412ebbdf97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1502a99e74954b5d1232f00e711bcb7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7219da2952e9f0d1f5aae7cbfd9bc108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e47454f437cb77378ad25d4addb5d7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eaac82b743a3ce93d04a9d4a097dd88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8399c34b757773ae3fcd6f92c2f0bb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7552d60808ab3a1453cd450376cb218
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e0827f577e67659415b26c05575e670 |
| publicationDate |
2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112957354-A |
| titleOfInvention |
Application of parthenolide in the preparation of MCR-1 enzyme inhibitor |
| abstract |
The invention relates to the application of parthenolide in the preparation of MCR-1 enzyme inhibitor. It is verified by a checkerboard method and a time-sterilization curve method that parthenolide can restore the effect of polymyxin on MCR-1 Escherichia coli, Klebsiella pneumoniae The bactericidal activity of Gram-negative Enterobacteriaceae such as bacteria and Salmonella, and the establishment of a mouse pneumonia infection model proves that parthenolide combined with polymyxin has a good therapeutic effect on MCR-1-producing bacteria infection. Therefore, parthenolide is an effective MCR-1 drug-resistant enzyme inhibitor, and when used in combination with polymyxin, it has a good experimental therapeutic effect on the infection of MCR-1-resistant bacteria. |
| priorityDate |
2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |