| abstract |
The present disclosure provides bispecific antibodies that specifically bind VEGF and ANG2, comprising an anti-VEGF antibody or antigen-binding fragment thereof that specifically binds VEGF and an anti-ANG2 single-domain antibody that specifically binds ANG2, wherein the anti-ANG2 single domain antibody specifically binds ANG2 The domain antibody is linked directly or indirectly to the anti-VEGF antibody or antigen-binding fragment thereof. The present disclosure also provides anti-ANG2 single-domain antibodies and antigen-binding fragments thereof, as well as preparation and application of the aforementioned antibodies. |