http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112941080-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-43504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 |
| filingDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112941080-B |
| titleOfInvention | Nucleic acid aptamers with high affinity for both ozonic acid and pinotoxin |
| abstract | The present invention discloses nucleic acid aptamers with high affinity for salicylic acid and pinotoxin, including two split-type aptamers DSP-1 and DSP-34, the nucleotide sequences of which are as shown in SEQ ID NO .1 and 2 are shown. The present invention also discloses another nucleic acid aptamer with high affinity for salicylic acid and pinotoxin, DSP-134, the nucleotide sequence of which is shown in SEQ ID NO.5. The Kd value of the aptamer DSP-1,34 of the present invention for binding to OA is 11.6 nM, and the Kd value for binding to DTX is 43.7 nM; the Kd value of the aptamer DSP-134 for binding to OA is 133 nM, and the The Kd value is 228nM; it has no ability to recognize marine toxins such as saxitoxin, neosaxitoxin, and genus toxin. According to the prediction of the secondary structure of the original aptamer, the present invention adopts the transformation method of first truncation and then splitting, so that the transformed aptamer has better affinity for the target, and has better affinity for both OA and DTX. Recognition ability. |
| priorityDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.