http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112939991-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49790ed5b8ddc5fa27a1d47732c612df |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 |
| filingDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce2206348f189dd72ce8d7cbf9cbbc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8520711d659be4a8f17d5e6bc450be4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3db73a2732c22d5940196b306f0c6b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1fcac648a7779b33c3c1e5618db1a7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_248df9ecd043db65ea913552e8e220e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c76c6ea7c1a08537972c307657f6b87d |
| publicationDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112939991-A |
| titleOfInvention | A kind of multi-substituted spirotetrahydrocarbazole and derivatives thereof, synthesis method and application thereof |
| abstract | The invention discloses a method for synthesizing polysubstituted spirotetrahydrocarbazole and derivatives thereof. The diazo compound and substituted indolinone are used as raw materials, Rh 2 (OAc) 4 is used as a catalyst, and in an organic solvent, Molecular sieve is a water-absorbing additive, and the product is obtained with high selectivity and high yield after a one-step two-component reaction. The method of the invention has the advantages of high atom economy, good selectivity, mild reaction conditions, high yield, simple and safe operation and the like. The tetrahydrocarbazole skeleton contained in the multi-substituted spirotetrahydrocarbazole compounds involved in the present invention is an important structural fragment of many complex natural products with biological activity. Therefore, such compounds can be used as important pharmaceutical and chemical compounds. Intermediates have broad application prospects in the pharmaceutical field. |
| priorityDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.