http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112939756-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-61 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-46 |
| filingDate | 2021-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112939756-B |
| titleOfInvention | A kind of improved process method for preparing 5-chlorindanone |
| abstract | The invention discloses an improved process method for preparing 5-chlorindanone, and belongs to the technical field of organic synthesis. Chlorobenzene is mixed with anhydrous aluminum trichloride, and 3-chloropropionyl chloride is added to carry out the Friedel-Crafts acylation reaction to obtain 3,4'-dichloropropiophenone, then in anhydrous aluminum chloride/sodium chloride or tri( Under the conditions of pentafluorophenyl) borane, the catalyzed ring is closed, and the 5-chlorindanone is obtained by direct rectification after the reaction finishes washing with water. The process of the invention directly distills after washing with water, without subsequent operations, reduces operation steps, shortens production man-hours, saves production costs, greatly improves the extraction effect of products, and increases the yield of products by more than 15%. It can be effectively removed, and the content of the product is increased to more than 99.5%. At the same time, the use of tris(pentafluorophenyl)borane to catalyze the ring closure can reduce the total amount of aluminum trichloride, reduce the ring closure reaction temperature, and reduce the generation of tar. , improving the yield of the product. |
| priorityDate | 2021-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.