Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
filingDate |
2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaef12b34fd26130a9404a22c382e80e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97f866a01537addeaae9e5e53b28b765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e763fc943d9491e0c5e742ef7a14ed7e |
publicationDate |
2021-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-112930399-A |
titleOfInvention |
Compositions and methods for enhancing donor oligonucleotide-based gene editing |
abstract |
Compositions for enhanced gene editing and methods of use thereof. The composition contains a cell penetrating antibody and a donor oligonucleotide containing a sequence that can correct the mutation in the genome of the cell. Preferably, the composition is free of nucleases, PNAs or nanoparticles. These compositions are used to modify the genome of a cell by contacting the cell with an effective amount of the composition. Genome modification occurs at a higher frequency both ex vivo and in vivo when cells are contacted with the cell penetrating antibody and the donor oligonucleotide than in the absence of the cell penetrating antibody. |
priorityDate |
2018-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |