http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112920421-B

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filingDate 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112920421-B
titleOfInvention Temperature-responsive polymer grafted gold nanoparticle composite quantum dot fluorescent probe and preparation method and application thereof
abstract The invention discloses a temperature-responsive polymer grafted gold nanoparticle composite quantum dot fluorescent probe and a preparation method and application thereof, wherein the preparation of the quantum dot fluorescent probe comprises the following steps: growing a silicon dioxide shell layer on the surface of the gold nano-particle to form Au @ SiO 2 (ii) a Isopropyl acrylamide monomer, acrylic acid, ammonium persulfate and Au @ SiO 2 Mixing in SiO 2 Surface polymerization to form SiO 2 Coating the surface with an isopropyl acrylamide monomer to obtain Au @ SiO 2 @ PNIPAM microspheres; mixing Au @ SiO 2 The @ PNIPAM microsphere is placed in EDC aqueous solution, and then the quantum dot modified by amino is added to carry out amidation reaction, so that the quantum dot is successfully connected with Au @ SiO 2 Forming Au @ SiO on the surface of the @ PNIPAM microsphere 2 @ PNIPAM-QDs fluorescent probes. The fluorescent probe prepared by the invention has sensitive temperature responsiveness and can be applied to temperature measurement.
priorityDate 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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