| abstract |
The present invention belongs to the field of medicinal chemistry, and relates to compounds as KRAS-G12C inhibitors and applications thereof. Specifically, the present invention provides compounds represented by formulas (I) and (II) or isomers and pharmaceutically acceptable salts thereof. , solvates, crystals or prodrugs, methods for their preparation and pharmaceutical compositions containing these compounds and uses of these compounds or compositions for the treatment of KRAS-G12C mutation-mediated diseases. |