| abstract |
Disclosed is an antigen binding molecule comprising an Fc region, the Fc region comprising a polypeptide having: (i) one or more of C at position 242, and C at position 334, and (i i) A at position 236, D at position 239, E at position 332, L at position 330, K at position 345, and G at position 430. Also disclosed are polypeptides that constitute such Fc regions, nucleic acids encoding such antigen binding molecules and polypeptides, compositions comprising such antigen binding molecules, polypeptides, and nucleic acids, and methods of using the same. |