http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112899309-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2021-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112899309-B |
| titleOfInvention | Cardiomyocyte-specific overexpression Snhg5 vector and method for constructing transgenic animal by using same |
| abstract | The invention constructs a transgenic vector alpha-MHC-Snhg 5-hGH for specifically over-expressing Snhg5 in myocardial cells, introduces the transgenic vector alpha-MHC-Snhg 5-hGH into fertilized eggs of animals, and transplants the fertilized eggs to obtain animal seeds stably carrying exogenous target genes to substitute for the transgenic mice of the myocardial cell specificity Snhg 5. Expression of Snhg5 in mouse heart tissue was detected, and Snhg5 was successfully overexpressed in the heart of cardiomyocyte-specific Snhg5 transgenic mice. The phenotype analysis of the system is carried out on the cardiomyocyte-specific Snhg5 transgenic mouse, the cardiomyocyte-specific Snhg5 transgenic mouse is found to be easier to generate cardiac hypertrophy and cardiac remodeling under the stimulation of pathological conditions, and the generated pathological changes are similar to human heart diseases, so that the establishment of the cardiomyocyte-specific Snhg5 transgenic mouse is possible to provide an ideal animal model for the treatment of the heart diseases and the drug screening. |
| priorityDate | 2021-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 243.