| abstract |
The present invention provides a long-acting modified glucagon peptide analog or a salt thereof and use thereof. The long-acting modified glucagon peptide analog: general formula I: X—Y—Z wherein, X is a polypeptide with the sequence of general formula i, Y is a linking arm connecting the polypeptide and the macromolecular polymer unit; Z is a macromolecular polymer unit, and X represents the general formula i: HX 2 QGTFTSDX 10 SKYLX 15 EX 17 AAX 20 EFX 23 X 24 WLLX 28 X 29 , wherein X 2 , X 10 , X 12 , X 15 , X 17 , X 18 , X 20 , X 23 , X 24 , X 28 , X 29 Definitions and claims and descriptions The definition is the same. The long-acting modified glucagon peptide analog of the present invention has the dual agonistic effect of GC/GLP-1 receptor, can effectively reduce blood sugar, reduce body weight, improve body fat level, and has significant and long-lasting effects. Compared with the prior art Better retention of in vivo activity and potential application in the treatment of metabolic diseases. |