| abstract |
The invention discloses a biomedical polyglyceryl hydrogel and a preparation method thereof, belonging to the field of biomedical materials and polymer chemistry. Adding natural polymer and gelatin into lactic acid aqueous solution, and fully stirring for dissolving; adding polyglycerol and poloxamer into the solution, and fully stirring and mixing; the pH was adjusted to 6.5 to 7.5 by dropwise addition of an aqueous NaOH solution, and the system was allowed to stand to obtain a polyglyceryl hydrogel. The hydrogel has the water content higher than 80%, and has better transparency and mechanical strength. The invention has the advantages that the polyglycerol with rich hydroxyl groups is used as the raw material, so that the hydrogel has higher water absorption and biocompatibility, in addition, the lactic acid is used for replacing the traditional glacial acetic acid as the natural high molecular dissolving auxiliary agent, so that the hydrogel is more environment-friendly and nontoxic, is easy to degrade and be absorbed by human bodies, and is expected to become a new biomedical material. |