http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112876524-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41cd56d9326625dec7f0865f8146bf95 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_870a3894189d5b30231dbfbd1f037f88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23c6553a37c8088582edd13e0612a672 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8bb1eefb4946cb91f7a19494296b247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71722641f3410893af70cfb4901f26f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2d2be79ee48ea632641d8a57f23e800 |
| publicationDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112876524-A |
| titleOfInvention | A kind of preparation method of Remdesivir intermediate |
| abstract | The invention discloses a preparation method of a remdesivir intermediate. First, 7-iodopyrrolo[2,1-f][1,2,4]triazine-4-amine and N,N-dimethyl Formamide dimethyl acetal reaction, then adding i-PrMgCl or butyllithium to the product in the previous step, then adding 2,3,5-tribenzyloxy-D-ribose acid-1,4-lactone, and finally Removing the protecting group to obtain remdesivir intermediate 1-C-(4-aminopyrrole[2,1-f][1,2,4]triazine-7-yl)-2,3,5-tri Oxy-(benzyl)-D-ribofuranose. The preparation method of the Redcivir intermediate of the present invention selects a mature product in the current market as a reactant, the raw materials are easily available, and the production cost is reduced; the process is simple, the time consumption is short, the production efficiency is high, the yield is high, and the reaction conditions are mild , the post-processing is simple and convenient, suitable for scale-up preparation, and has great application prospects. |
| priorityDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.