http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112876413-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-42 |
| filingDate | 2021-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112876413-B |
| titleOfInvention | Preparation and antiviral activity of 2-(isoquinolin-1(2H)-one-4-yl)difluoroacetyl derivatives |
| abstract | The present invention relates to the preparation and antiviral activity of a 2-(isoquinoline-1(2H)-keto-4-yl) difluoroacetyl derivative. The preparation method of compound, comprises the following steps: dissolving raw material different isoquinoline-1 (2H)-ketone and different 2,2-difluoro-2-bromoacetate or amide in cyclohexane, then adding ligand and palladium catalyst, react at 20～150 ℃ for 6～36 hours, after the reaction terminates, separate and purify the crude product to obtain 2-(isoquinoline-1(2H)-keto-4-yl)difluoroacetyl derivative. The advantages of the method are: the raw materials are simple and easy to obtain, the operation is simple, the yield is high, the substrate adaptability is wide, and the prepared product is easy to purify. All the obtained compounds have good antiviral activity. |
| priorityDate | 2021-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.