| abstract |
The application of TRIM21 as a drug target for the treatment of osteoporosis and knee osteoarthritis relates to the field of biomedicine, and the application of TRIM21 as a therapeutic target and/or a small molecule drug screening target in the treatment of osteoporosis drugs. As a drug target, TRIM21 is used in the treatment of osteoporosis and knee osteoarthritis. By down-regulating TRIM21, it can inhibit the differentiation and function of osteoclasts, and increase the proliferation of bone marrow mesenchymal stem cells, thereby regulating osteoblast mediators. The dynamic balance between osteoclast-mediated bone formation and osteoclast-mediated bone resorption can achieve the effect of treating osteoporosis; down-regulating or inhibiting the expression and function of TRIM21 can improve subchondral bone remodeling, improve the symptoms and progression of knee osteoarthritis . |