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filingDate 2021-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112852678-A
titleOfInvention A strain of Enterobacter Chengdui producing nicotinamide mononucleotide and its application
abstract The invention provides an Enterobacter chengdus strain producing nicotinamide mononucleotide and an application thereof, and relates to the technical field of strain screening and application. The Enterobacter Chengdui of the present invention collects soil from the vicinity of the sewers of a factory producing NMN-related products, selects strains with strong ability to transform nicotinamide into nicotinamide mononucleotide in the soil through primary screening and re-screening, and carries out Identification and preservation, it is determined that the Enterobacter is a Gram-negative bacteria and belongs to the genus Enterobacter Chengdu. When nicotinamide was used as the substrate to use the Enterobacter chengdu to ferment NMN, the NMN yield reached 67.66 μM at 15 min, that is, 22.6 mg/L, indicating that the wild strain had a strong activity of synthesizing NMN and reduced the ability to synthesize NMN. It is dependent on Nampt and has a high scale application prospect.
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