| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d80f7b491bd2748fe5d249c95bdea5ee |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20034 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bdb0d718cfa36eaeab707ffdbdd6d04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7d90240ce69d4931d4feb17d6a3419f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15fb55e38a86cc3bfc697786d9881635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c88bde8ab62d7e11a4c3195134b6d376
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d682bf79fe006ce4e987fbedaf8c2d35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_315a3bcb650f5f9c055618acd5f5ebb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c63d61fa317c0edaa442245e6e020ea7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_196c4e0882c59f71f1dd481da314a005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26944878d2927a973a6710c3d7c20e52 |
| publicationDate |
2021-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112851824-A |
| titleOfInvention |
Fusion protein and application thereof in preparation of novel coronavirus subunit vaccine |
| abstract |
The invention discloses a fusion protein and application thereof in preparing a novel coronavirus subunit vaccine. The fusion protein comprises an RBD region of S protein of SARS-CoV-2 virus and an Fc region of IgG antibody which are fused and expressed. The invention obtains recombinant fusion protein by fusion expression of RBD structure domain of spinous process protein of SARS-CoV-2 and immunoglobulin Fc, the hinge region and constant region of Fc can combine two heavy chains of IgG antibody by disulfide bond to realize dimer of RBD, and the prepared recombinant fusion protein can be used as recombinant protein vaccine for novel coronavirus pneumonia. The recombinant protein vaccine can induce and generate high-titer specific IgG antibodies and neutralizing antibodies in a mouse body, the antibody level can be maintained for more than 3 months, and the vaccine can simultaneously induce the mouse to generate cellular immunity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116023511-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114014940-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113912738-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114574502-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114196701-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114196701-B |
| priorityDate |
2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |