| abstract |
The present application belongs to the technical field of biomedicine, and more particularly, the present application relates to a humanized single-domain antibody that binds serum albumin and multispecific antibodies, fusion proteins and conjugates comprising the single-domain antibody. The humanized single domain antibody of the present application can efficiently bind to human serum albumin, thereby prolonging the in vivo half-life of the molecule linked thereto. The humanized single-domain antibodies of the present application and the multispecific antibodies, fusion proteins and conjugates comprising the single-domain antibodies can be used to prepare the prevention and/or treatment or adjuvant treatment of tumors, infections, autoimmune diseases, metabolism-related diseases Medications for disease or development-related disorders. |