| abstract |
The present invention provides a substituted steroid compound and its application. Specifically, the substituted steroid compound of the present invention is a steroid compound represented by formula (I), or its crystal form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate or solvent compound. The substituted steroid compound disclosed in the present invention and the composition comprising the compound have excellent inhibitory activity on CYP17 enzyme and androgen receptor (AR), and have better pharmacokinetic parameter characteristics, and can improve the compound's drug concentration in animals to improve drug efficacy and safety. |