http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112851740-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0066 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112851740-B |
| titleOfInvention | G protein-coupled bile acid receptor endogenous ligand derivatives and their preparation methods and their applications in antitumor activity |
| abstract | The invention belongs to the field of medicinal chemistry, and specifically discloses a G protein-coupled bile acid receptor endogenous ligand derivative, a preparation method and an application in antitumor activity. The present invention uses different cholic acid parent structures as raw materials, carries out esterification reaction under the action of a catalyst, is protected by a protective group and then methylated, and finally obtains a series of new cholic acid series derivatives through deprotection, hydrolysis reaction and amide coupling reaction thing. The invention uses MTT colorimetry to test the anticancer activity of the synthesized new derivatives, and the results show that the synthesized series of G protein-coupled bile acid receptor endogenous ligand derivatives have good anticancer activity. |
| priorityDate | 2021-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.