| abstract |
The invention relates to the field of medicinal chemistry, in particular to the use of a brefeldin A ester derivative in inhibiting tumor proliferation activity, and can be used for preventing or treating hyperproliferative diseases, the brefeldin A ester The derivative-like structure is shown in formula (I). Among them, hyperproliferative diseases include liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Barter's esophagus cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphatic cancer, kidney cancer, brain cancer, Nerve cancer, nasopharyngeal cancer, oral cancer, colorectal cancer, so Brefeldin A ester derivatives have the potential to be developed as new antitumor drugs. |