| abstract |
The present invention relates to the field of medicinal chemistry, in particular to the application of a brefeldin A ester derivative in inhibiting tumor proliferation, the structure of the brefeldin A ester derivative is shown in formula (I) . The new compound of the present invention is effective in preventing or treating hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bartter's esophagus cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma , kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer, colorectal cancer, and has the potential to be developed as a new type of anti-tumor drug. |