http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112843088-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/D04H1-728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6957 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/D01D5-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/D01D5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/D04H1-728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-04 |
| filingDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112843088-B |
| titleOfInvention | A dual drug-loaded electrospinning nanofiber scaffold and its preparation method and application |
| abstract | The invention discloses a double-drug-loading electrospinning nanofiber scaffold and a preparation method and application thereof. The scaffold uses a PCL electrospinning nanofiber membrane loaded with CUR as a skeleton structure, the surface of the nanofiber is covered with a polydopamine membrane, and the surface of the polydopamine membrane is loaded with selenium nanoparticles. The preparation is as follows: PCL electrospinning nanofiber membrane loaded with CUR is obtained by electrospinning, then immersed in Tris-HCl buffer solution containing dopamine, stirred in the dark, and coated with PDA membrane; and finally immersed in a solution containing SeNPs , and load SeNPs on the surface of the PDA membrane to obtain a scaffold. The obtained scaffold has good biocompatibility, has pH response, and is loaded with two anticancer drugs, CUR and SeNPs, which can effectively release CUR, and has the dual effect of promoting skin tissue healing and anti-tumor, and can reduce chemotherapy toxicity and drug resistance, significantly Improve stent utilization, sensitivity and anticancer efficacy. |
| priorityDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.