| abstract |
The invention belongs to the field of pharmaceutical preparations, and relates to a substituted butenamide pharmaceutical composition and a preparation method thereof. The pharmaceutical composition contains (E)-N-(3-cyano-7-ethoxy-4-(3- Ethynylphenylamino)quinoline-6-yl)-4-(dimethylamino)but-2-enamide maleate 5-50 parts, filler 40-120 parts, disintegrating agent 2-20 parts 0-6 parts of binder, 0.5-5 parts of lubricant, the filler is selected from carbohydrates, the pharmaceutical composition has the beneficial effects of good quality stability and suitable for large-scale production. |